Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 6/20 | 0.80 |
| ▸ | AURKA | O14965 | 2/20 | 0.80 |
| ▸ | KDR | P35968 | 9/20 | 0.76 |
| ▸ | EGFR | P00533 | 8/20 | 0.75 |
| ▸ | RET | P07949 | 2/20 | 0.75 |
| ▸ | LCK | P06239 | 1/20 | 0.73 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.69 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | FLT3 | P36888 | 1/20 | 0.68 |
| ▸ | JAK3 | P52333 | 1/20 | 0.68 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.68 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.68 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.68 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.68 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8809205 | 0.99 | AURKB (0.78) | AURKBAURKAKDREGFRRET | |
| Anilinoquinazoline1 SCHEMBL1066538 | 0.89 | AURKB (1.00) | AURKBAURKAKDREGFRMAPK14 | |
| Anilinoquinazoline1 SCHEMBL30195580 | 0.89 | AURKB (1.00) | AURKBAURKAKDREGFRMAPK14 | |
| SCHEMBL8933899 | 0.88 | AURKB (0.94) | AURKBAURKAKDREGFRMAPK14 | |
| Anilinoquinazoline1 SCHEMBL3968007 | 0.88 | AURKB (0.98) | AURKBAURKAKDREGFRMAPK14 | |
| Hydrochloric Acid SCHEMBL8807604 | 0.87 | EGFR (0.76) | AURKBAURKAKDREGFRRET | |
| SCHEMBL5473733 | 0.87 | KDR (0.74) | AURKBAURKAKDREGFRRET | |
| Hydrochloric Acid SCHEMBL8807597 | 0.87 | AURKB (0.92) | AURKBAURKAKDREGFRLCK | |
| SCHEMBL27737748 | 0.87 | AURKB (0.74) | AURKBAURKAKDREGFRRET | |
| SCHEMBL1387182 | 0.86 | EGFR (0.94) | AURKBAURKAKDREGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10548897-B2 | KSR antagonists | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2020-02-04 | — | — | US | disclosed |
| WO-2016168704-A1 | KSR ANTAGONISTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10548897-B2 | KSR antagonists | KSR1, KSR2, KRAS | AURKB 339/4885AURKA 532/4885KDR 1123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.