Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 4/20 | 0.60 |
| ▸ | AURKA | O14965 | 14/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.49 |
| ▸ | PAK4 | O96013 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 8/20 | 0.47 |
| ▸ | SRC | P12931 | 7/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165894 | 0.93 | PLK4 (0.58) | PLK4AURKAAURKBPAK4NTRK1 | |
| SCHEMBL19990812 | 0.92 | PLK4 (0.61) | PLK4AURKAAURKBPAK4NTRK1 | |
| SCHEMBL18165956 | 0.90 | PLK4 (0.63) | PLK4AURKAAURKBPAK4NTRK1 | |
| SCHEMBL18154793 | 0.89 | PLK4 (0.68) | PLK4AURKAAURKBPAK4NTRK1 | |
| SCHEMBL18165855 | 0.88 | PLK4 (0.54) | PLK4AURKAAURKBPAK4NTRK1 | |
| SCHEMBL18165908 | 0.88 | PLK4 (0.53) | PLK4AURKAAURKBPAK4NTRK1 | |
| SCHEMBL18165962 | 0.87 | PLK4 (0.54) | PLK4AURKAAURKBPAK4NTRK1 | |
| SCHEMBL18154818 | 0.86 | PLK4 (0.59) | PLK4AURKAAURKBPAK4NTRK1 | |
| SCHEMBL18154766 | 0.86 | PLK4 (0.71) | PLK4AURKAAURKBPAK4NTRK1 | |
| SCHEMBL18165815 | 0.86 | PLK4 (0.52) | PLK4AURKAAURKBPAK4NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016166604-A1 | PLK4 INHIBITORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2016-10-20 | — | — | WO | disclosed |