Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 12/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165979 | 0.79 | AURKA (0.44) | MEN1HTTKMT2AHSD17B10PLK4 | |
| SCHEMBL12102888 | 0.78 | GSK3B (0.50) | MEN1HTTKMT2AHSD17B10PLK4 | |
| SCHEMBL25260418 | 0.73 | BRAF (0.39) | MEN1HTTKMT2AHSD17B10LMNA | |
| SCHEMBL30448315 | 0.73 | BRAF (0.39) | MEN1HTTKMT2AHSD17B10LMNA | |
| SCHEMBL25619858 | 0.72 | SMN1; SMN2 (0.50) | MEN1HTTKMT2AHSD17B10LMNA | |
| SCHEMBL4909730 | 0.71 | IGF1R (0.43) | MEN1HTTKMT2AHSD17B10PLK4 | |
| SCHEMBL15722708 | 0.71 | PIK3C3 (0.47) | AURKAAURKBPIK3C3RETIGF1R | |
| SCHEMBL18166013 | 0.70 | AURKB (0.66) | PLK4AURKAAURKBGSK3BSRC | |
| SCHEMBL219046 | 0.67 | PAK4 (0.59) | MEN1HTTKMT2AHSD17B10PLK4 | |
| SCHEMBL22600946 | 0.67 | PAK4 (0.59) | MEN1HTTKMT2AHSD17B10PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752612-B2 | PLK4 inhibitors | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2020-08-25 | — | — | US | disclosed |
| US-20180086739-A1 | PLK4 INHIBITORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2018-03-29 | — | — | US | disclosed |
| US-20180086739-A1 | PLK4 INHIBITORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2018-03-29 | — | — | US | disclosed |
| WO-2016166604-A1 | PLK4 INHIBITORS | LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086739-A1 | PLK4 INHIBITORS | PLK4, PLK2, PLK3 | MEN1 3811/4885HTT 3287/4885KMT2A 1312/4885 |
| US-10752612-B2 | PLK4 inhibitors | PLK4, PLK2, PLK3 | MEN1 3811/4885HTT 3287/4885KMT2A 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.