Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12475633 | 1.00 | AKT1 (1.00) | AKT1PIK3CDCYP3A4PIK3CB | |
| SCHEMBL18166252 | 1.00 | AKT1 (1.00) | AKT1PIK3CDCYP3A4PIK3CB | |
| SCHEMBL18166259 | 0.93 | AKT1 (1.00) | AKT1 | |
| SCHEMBL12475536 | 0.93 | AKT1 (1.00) | AKT1 | |
| SCHEMBL18166227 | 0.93 | AKT1 (1.00) | AKT1 | |
| SCHEMBL12476368 | 0.90 | AKT1 (1.00) | AKT1PIK3CDCYP3A4PIK3CB | |
| SCHEMBL18166255 | 0.90 | AKT1 (1.00) | AKT1 | |
| SCHEMBL12476010 | 0.90 | AKT1 (1.00) | AKT1PIK3CDCYP3A4PIK3CB | |
| SCHEMBL12475800 | 0.90 | AKT1 (1.00) | AKT1PIK3CDCYP3A4PIK3CB | |
| SCHEMBL18166224 | 0.90 | AKT1 (1.00) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2658844-B1 | NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI SA (FR) | 2016-10-26 | — | — | EP | claimed |
| EP-2658844-B1 | NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS | SANOFI SA (FR) | 2016-10-26 | — | — | EP | disclosed |