Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.78 |
| ▸ | ATM | Q13315 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | STAT1 | P42224 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166543 | 0.87 | KDM4E (1.00) | TSHRKDM4EATMRXFP1NPC1 | |
| SCHEMBL10113950 | 0.87 | KDM4E (0.78) | TSHRKDM4EATMRXFP1SMN1; SMN2 | |
| SCHEMBL10113944 | 0.85 | KDM4E (0.85) | TSHRKDM4EATMRXFP1TP53 | |
| SCHEMBL18166760 | 0.85 | KDM4E (0.77) | TSHRKDM4EATMRXFP1SMN1; SMN2 | |
| SCHEMBL18166564 | 0.85 | KDM4E (0.77) | TSHRKDM4EATMRXFP1SMN1; SMN2 | |
| SCHEMBL18166769 | 0.83 | KDM4E (0.72) | TSHRKDM4EATMRXFP1SMN1; SMN2 | |
| SCHEMBL18166652 | 0.83 | RXFP1 (0.65) | TSHRKDM4EATMGAARXFP1 | |
| SCHEMBL10114083 | 0.83 | KDM4E (0.73) | TSHRKDM4EATMRXFP1SMN1; SMN2 | |
| SCHEMBL10113978 | 0.82 | KDM4E (0.73) | TSHRKDM4EATMRXFP1SMN1; SMN2 | |
| SCHEMBL18166688 | 0.82 | KDM4E (0.73) | TSHRKDM4EATMRXFP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663295-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | ELI LILLY AND CO. (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2170309-B1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | HYDRA BIOSCIENCES INC (US) | 2016-10-26 | — | — | EP | disclosed |