Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166762 | 0.93 | MAPT (0.72) | MAPTSMN1; SMN2LMNARXFP1KDM4E | |
| SCHEMBL18166573 | 0.92 | MAPT (0.73) | MAPTSMN1; SMN2LMNARXFP1KDM4E | |
| SCHEMBL18166672 | 0.90 | MAPT (0.73) | MAPTSMN1; SMN2LMNARXFP1KDM4E | |
| SCHEMBL18166721 | 0.89 | MAPT (0.80) | MAPTSMN1; SMN2LMNARXFP1PORCN | |
| SCHEMBL18166595 | 0.88 | MAPT (0.80) | MAPTSMN1; SMN2LMNARXFP1PORCN | |
| SCHEMBL18166692 | 0.87 | MAPT (0.76) | MAPTSMN1; SMN2LMNARXFP1PORCN | |
| SCHEMBL18166626 | 0.87 | MAPT (0.77) | MAPTSMN1; SMN2LMNARXFP1PORCN | |
| SCHEMBL9972920 | 0.86 | MAPT (0.77) | MAPTSMN1; SMN2LMNARXFP1PORCN | |
| SCHEMBL3248648 | 0.86 | MAPT (0.80) | MAPTSMN1; SMN2LMNARXFP1KDM4E | |
| SCHEMBL18166750 | 0.85 | SMN1; SMN2 (0.75) | MAPTSMN1; SMN2LMNARXFP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663295-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | ELI LILLY AND CO. (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2170309-B1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | HYDRA BIOSCIENCES INC (US) | 2016-10-26 | — | — | EP | disclosed |