Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15618198 | 0.85 | MKNK1 (0.53) | MKNK1MAPTCDC7ROCK2MAP4K4 | |
| SCHEMBL17026036 | 0.82 | MKNK1 (0.57) | MKNK1SYKKIF11EGFRERBB2 | |
| SCHEMBL17026139 | 0.82 | MKNK1 (0.66) | MKNK1MAPTCDC7ROCK2MAP4K4 | |
| SCHEMBL15618235 | 0.81 | MKNK1 (0.56) | MKNK1MAPTSMN1; SMN2SYKKIF11 | |
| SCHEMBL15618243 | 0.80 | MKNK1 (0.49) | MKNK1MAPTROCK2IRAK4SMN1; SMN2 | |
| SCHEMBL18167313 | 0.80 | MKNK1 (0.53) | MKNK1MAPTSMN1; SMN2SYKKIF11 | |
| SCHEMBL15618313 | 0.79 | MKNK1 (0.62) | MKNK1MAPTCDC7ROCK2MAP4K4 | |
| SCHEMBL15618203 | 0.78 | MKNK1 (0.53) | MKNK1IRAK4SYKKIF11EGFR | |
| SCHEMBL15618350 | 0.75 | MKNK1 (0.53) | MKNK1EGFR | |
| SCHEMBL15618290 | 0.74 | MKNK1 (0.55) | MKNK1MAPTSMN1; SMN2SYKKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897957-B1 | SUBSTITUTED PYRROLOPYRIMIDINYLAMINO-BENZOTHIAZOLONES AS MKNK KINASE INHIBITORS | Bayer Pharma AG (DE) | 2016-10-26 | — | — | EP | claimed |