Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.68 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PLD2 | O14939 | 5/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 4/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788329 | 0.87 | PIK3CD (0.67) | PIK3CDPIK3R1ALDH1A1KDM4EPMP22 | |
| SCHEMBL788325 | 0.86 | PIK3CD (0.76) | PIK3CDPIK3R1ALDH1A1KDM4EPMP22 | |
| SCHEMBL15485458 | 0.81 | PIK3CD (0.79) | PIK3CDPIK3R1ALDH1A1KDM4EPMP22 | |
| SCHEMBL796348 | 0.81 | PIK3CD (0.83) | PIK3CDPIK3R1ALDH1A1KDM4EPMP22 | |
| SCHEMBL788667 | 0.81 | PIK3CD (0.75) | PIK3CDPIK3R1ALDH1A1KDM4EPMP22 | |
| SCHEMBL787981 | 0.81 | PIK3CD (1.00) | PIK3CDPIK3R1ALDH1A1KDM4EPMP22 | |
| SCHEMBL794661 | 0.80 | PIK3CD (0.85) | PIK3CDPIK3R1PLD2PLD1PDE2A | |
| SCHEMBL793985 | 0.80 | PIK3CD (0.69) | PIK3CDPIK3R1ALDH1A1KDM4EPMP22 | |
| SCHEMBL787863 | 0.80 | PIK3CD (0.82) | PIK3CDPIK3R1ALDH1A1KDM4EPMP22 | |
| SCHEMBL788094 | 0.80 | PIK3CD (0.71) | PIK3CDPIK3R1ALDH1A1KDM4EPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616469-B1 | 9H-PURINE COMPOUNDS AS PI3K-DELTA INHIBITORS AND METHODS FOR THEIR MANUFACTURE | EXELIXIS INC (US) | 2016-10-26 | — | — | EP | claimed |