Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18168717 | 1.00 | IDH1 (0.58) | IDH1 | |
| SCHEMBL18168303 | 0.88 | IDH1 (0.52) | IDH1 | |
| SCHEMBL18168664 | 0.88 | IDH1 (0.66) | IDH1 | |
| SCHEMBL18168500 | 0.88 | IDH1 (0.66) | IDH1 | |
| SCHEMBL18168650 | 0.87 | IDH1 (0.51) | IDH1 | |
| SCHEMBL18168397 | 0.87 | IDH1 (0.51) | IDH1 | |
| SCHEMBL18168496 | 0.86 | IDH1 (0.50) | IDH1 | |
| SCHEMBL18168633 | 0.86 | IDH1 (0.50) | IDH1 | |
| SCHEMBL18168326 | 0.86 | IDH1 (0.50) | IDH1 | |
| SCHEMBL18168748 | 0.86 | IDH1 (0.53) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407419-B2 | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors | FORMA THERAPEUTICS, INC. (US) | 2019-09-10 | — | — | US | claimed |
| US-20180118732-A1 | QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. | 2018-05-03 | — | — | US | claimed |
| US-9624216-B2 | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors | FORMA THERAPEUTICS, INC. (US) | 2017-04-18 | — | — | US | claimed |
| US-20160311818-A1 | QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. | 2016-10-27 | — | — | US | claimed |
| US-10807976-B2 | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors | FORMA THERAPEUTICS, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-10407419-B2 | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors | FORMA THERAPEUTICS, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-20180118732-A1 | QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. | 2018-05-03 | — | — | US | disclosed |
| US-9624216-B2 | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors | FORMA THERAPEUTICS, INC. (US) | 2017-04-18 | — | — | US | disclosed |
| US-20160311818-A1 | QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407419-B2 | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors | IDH1, IDH3A, IDH2 | IDH1 1/4885 |
| US-20160311818-A1 | QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | IDH1, IDH3A, IDH2 | IDH1 1/4885 |
| US-20180118732-A1 | QUINOLINONE FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | IDH1, IDH3A, IDH2 | IDH1 1/4885 |
| US-10807976-B2 | Quinolinone five-membered heterocyclic compounds as mutant-isocitrate dehydrogenase inhibitors | IDH1, IDH3A, IDH2 | IDH1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.