Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.60 |
| ▸ | RAB9A | P51151 | 9/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | TP53 | P04637 | 5/20 | 0.60 |
| ▸ | PKM | P14618 | 4/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | METAP2 | P50579 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | METAP1 | P53582 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30634854 | 0.77 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL30561047 | 0.77 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL172216 | 0.77 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1272832 | 0.76 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18171543 | 0.76 | METAP1 (0.62) | METAP2METAP1 | |
| Water SCHEMBL9817804 | 0.75 | NPC1 (0.95) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL28888422 | 0.75 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL28451643 | 0.75 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL31509605 | 0.74 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL29079508 | 0.74 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10118920-B2 | Isoxazolyl substituted benzimidazoles | CELLCENTRIC LTD (GB) | 2018-11-06 | — | — | US | claimed |
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2018-05-10 | — | — | US | claimed |
| CN-107750249-A | The benzimidazole of isoxazolyl substitution | 塞尔森瑞科有限责任公司 | 2018-03-02 | — | — | CN | claimed |
| EP-3286183-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | Cellcentric Ltd (GB) | 2018-02-28 | — | — | EP | claimed |
| WO-2016170324-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2016-10-27 | — | — | WO | claimed |
| CN-115716822-B | Application of benzimidazolyl isoxazoles in preparation of medicines related to multiple myeloma | 徐州医科大学 | 2025-05-16 | — | — | CN | disclosed |
| CN-115716822-A | Application of benzimidazolyl isoxazole compound in preparation of medicines related to multiple myeloma | 徐州医科大学 | 2023-02-28 | — | — | CN | disclosed |
| CN-115716822-A | Application of benzimidazolyl isoxazole compound in preparation of medicines related to multiple myeloma | 徐州医科大学 | 2023-02-28 | — | — | CN | disclosed |
| CN-115716822-A | Application of benzimidazolyl isoxazole compound in preparation of medicines related to multiple myeloma | 徐州医科大学 | 2023-02-28 | — | — | CN | disclosed |
| CN-107750251-B | Isoxazolyl-substituted imidazopyridines | 塞尔森瑞科有限责任公司 | 2020-09-01 | — | — | CN | disclosed |
| US-10428065-B2 | Isoxazolyl substituted imidazopyridines | CELLCENTRIC LTD (GB) | 2019-10-01 | — | — | US | disclosed |
| EP-3286188-B1 | ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES | CELLCENTRIC LTD (GB) | 2019-03-20 | — | — | EP | disclosed |
| CN-107750249-A | The benzimidazole of isoxazolyl substitution | 塞尔森瑞科有限责任公司 | 2018-03-02 | — | — | CN | disclosed |
| EP-3286183-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | Cellcentric Ltd (GB) | 2018-02-28 | — | — | EP | disclosed |
| EP-3286183-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | Cellcentric Ltd (GB) | 2018-02-28 | — | — | EP | disclosed |
| EP-3286188-A1 | ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES | Cellcentric Ltd (GB) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170324-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016170324-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016170323-A1 | ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES | CELLCENTRIC LTD (GB) | 2016-10-27 | — | — | WO | disclosed |
| CN-1221851-C | Silver halide photographic material | FUJI PHOTO FILM CO LTD (JP) | 2005-10-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | EP300, HDAC3, HDAC1 | NPC1 1768/4885RAB9A 2083/4885SMN1; SMN2 3712/4885 |
| US-10428065-B2 | Isoxazolyl substituted imidazopyridines | EP300, HDAC3, HDAC1 | NPC1 1153/4885RAB9A 1458/4885SMN1; SMN2 3154/4885 |
| US-10118920-B2 | Isoxazolyl substituted benzimidazoles | EP300, HDAC3, HDAC1 | NPC1 1768/4885RAB9A 2083/4885SMN1; SMN2 3712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.