Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (R,R)-Tramadol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 9/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.71 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R,R)-Tramadol SCHEMBL2678627 | 0.91 | SLC6A2 (0.82) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL14780285 | 0.90 | SLC6A2 (0.66) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL14320250 | 0.89 | SLC6A2 (0.65) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL16710349 | 0.89 | SLC6A2 (0.63) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL16707251 | 0.89 | SLC6A2 (0.63) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Tramadol SCHEMBL4799725 | 0.88 | SLC6A2 (0.76) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL2678948 | 0.88 | SLC6A2 (0.76) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL2678195 | 0.87 | SLC6A2 (0.89) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| Tramadol SCHEMBL4798126 | 0.85 | SLC6A2 (0.82) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 | |
| (R,R)-Tramadol SCHEMBL2678357 | 0.85 | SLC6A2 (0.82) | SLC6A2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3346991-A1 | PROTECTING ORAL OVERDOSE WITH ABUSE DETERRENT IMMEDIATE RELEASE FORMULATIONS | Grünenthal GmbH (DE) | 2018-07-18 | — | — | EP | disclosed |
| EP-3285747-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES | Grünenthal GmbH (DE) | 2018-02-28 | — | — | EP | disclosed |
| EP-3285748-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM DIFFERENT PARTICLES | Grünenthal GmbH (DE) | 2018-02-28 | — | — | EP | disclosed |
| EP-3285746-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER | Grünenthal GmbH (DE) | 2018-02-28 | — | — | EP | disclosed |
| WO-2017042325-A1 | PROTECTING ORAL OVERDOSE WITH ABUSE DETERRENT IMMEDIATE RELEASE FORMULATIONS | Grünenthal GmbH (DE) | 2017-03-16 | — | — | WO | disclosed |
| WO-2016170094-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES | Grünenthal GmbH (DE) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016170096-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM DIFFERENT PARTICLES | Grünenthal GmbH (DE) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016170095-A1 | TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER | Grünenthal GmbH (DE) | 2016-10-27 | — | — | WO | disclosed |