Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.47 |
| ▸ | UGCG | Q16739 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172156 | 0.87 | SCN9A (0.77) | SCN9ASCN5AUGCGMAPK14F10 | |
| SCHEMBL18172171 | 0.87 | SCN9A (0.78) | SCN9ASCN5AF10MAPTNPC1 | |
| SCHEMBL18172190 | 0.76 | SCN9A (0.67) | SCN9ASCN5AUGCGMAPK14LCK | |
| SCHEMBL18172225 | 0.75 | SCN9A (0.60) | SCN9ASCN5AMAPK14LCKCYP2C9 | |
| SCHEMBL18172119 | 0.75 | SCN9A (1.00) | SCN9ASCN5AF10NPC1RAB9A | |
| SCHEMBL18172107 | 0.74 | SCN9A (0.80) | SCN9ASCN5AF10NPC1RAB9A | |
| SCHEMBL18172037 | 0.74 | SCN9A (0.75) | SCN9ASCN5AMAPK14F10MAPT | |
| SCHEMBL18172191 | 0.74 | SCN9A (0.75) | SCN9ASCN5AF10MAPTNPC1 | |
| SCHEMBL18172175 | 0.74 | SCN9A (0.62) | SCN9ASCN5AF10KMT2ANPC1 | |
| SCHEMBL18172018 | 0.73 | SCN9A (0.72) | SCN9ASCN5AMAPK14F10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286178-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | Almirall S.A. (ES) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170009-A1 | AMINO-SUBSTITUTED HETEROCYCLIC DERIVATIVES AS SODIUM CHANNEL INHIBITORS | ALMIRALL, S.A. (ES) | 2016-10-27 | — | — | WO | disclosed |