Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20061678 | 1.00 | MAPT (0.41) | MAPTALDH1A1KDM4ESMN1; SMN2CFTR | |
| SCHEMBL15649492 | 0.78 | KMT2A (0.39) | MAPTALDH1A1KDM4EGAANPSR1 | |
| SCHEMBL18172316 | 0.76 | MAPT (0.52) | MAPTALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL20061677 | 0.76 | MAPT (0.52) | MAPTALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL7885980 | 0.76 | MAPT (0.45) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL16722341 | 0.75 | KDR (0.40) | MAPTALDH1A1CDK1P2RX3P2RX2 | |
| SCHEMBL16722344 | 0.75 | KDR (0.40) | MAPTALDH1A1CDK1P2RX3P2RX2 | |
| SCHEMBL789781 | 0.75 | HTT (0.42) | MAPTALDH1A1KDM4ESMN1; SMN2CHEK1 | |
| SCHEMBL1619871 | 0.72 | KMT2A (0.43) | MAPTALDH1A1KDM4ESMN1; SMN2CHEK1 | |
| SCHEMBL906615 | 0.72 | CYP1A2 (0.41) | ALDH1A1KDM4EP2RX3P2RX2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286188-B1 | ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES | CELLCENTRIC LTD (GB) | 2019-03-20 | — | — | EP | disclosed |
| US-20180105519-A1 | ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES | CELLCENTRIC LTD (GB) | 2018-04-19 | — | — | US | disclosed |
| EP-3286188-A1 | ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES | Cellcentric Ltd (GB) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016170323-A1 | ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES | CELLCENTRIC LTD (GB) | 2016-10-27 | — | — | WO | disclosed |
| WO-2016170323-A1 | ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES | CELLCENTRIC LTD (GB) | 2016-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105519-A1 | ISOXAZOLYL SUBSTITUTED IMIDAZOPYRIDINES | EP300, HDAC3, HDAC1 | MAPT 4493/4885ALDH1A1 886/4885KDM4E 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.