Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 13/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172441 | 0.89 | P2RY14 (0.40) | P2RY14HSD11B1MAPTSCN9A | |
| SCHEMBL18172398 | 0.88 | P2RY14 (0.40) | P2RY14LMNAHSD11B1MAPT | |
| SCHEMBL18172506 | 0.86 | P2RY14 (0.41) | P2RY14ALOX5APFEN1HSD11B1MAPT | |
| SCHEMBL18172487 | 0.86 | P2RY14 (0.56) | P2RY14LMNAOPRD1TMEM97KCNH2 | |
| SCHEMBL18172456 | 0.86 | P2RY14 (0.41) | P2RY14OPRD1TMEM97KCNH2SCN9A | |
| SCHEMBL18172390 | 0.83 | P2RY14 (0.35) | P2RY14KCNH2SCN9A | |
| SCHEMBL18172392 | 0.83 | P2RY14 (0.40) | P2RY14LMNATP53MAPT | |
| SCHEMBL18172356 | 0.82 | P2RY14 (0.35) | P2RY14LMNA | |
| SCHEMBL18172409 | 0.81 | P2RY14 (0.42) | P2RY14KCNH2HSD11B1TP53MAPT | |
| SCHEMBL18172495 | 0.80 | P2RY14 (0.36) | P2RY14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286182-A1 | TETRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | F. Hoffmann-La Roche AG (CH) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016169902-A1 | TETRAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-10-27 | — | — | WO | disclosed |