Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1814874 | 0.90 | CYP2C9 (0.38) | PDE3BPDE3ACYP2C9NPC1RIPK2 | |
| SCHEMBL1816305 | 0.87 | CYP2C9 (0.37) | PDE3BPDE3ACYP2C9NPC1MEN1 | |
| SCHEMBL1817268 | 0.86 | CYP2C9 (0.53) | PDE3BPDE3ACYP2C9NPC1RIPK2 | |
| SCHEMBL1817305 | 0.85 | CYP2C9 (0.37) | PDE3BPDE3ACYP2C9NPC1MEN1 | |
| SCHEMBL1819876 | 0.85 | CCNA2 (0.42) | PDE3BPDE3ACYP2C9NPC1RIPK2 | |
| SCHEMBL12818264 | 0.80 | PDE3B (0.39) | PDE3BPDE3ACYP2C9NPC1RIPK2 | |
| SCHEMBL12818233 | 0.79 | PDE3B (0.42) | PDE3BPDE3ACYP2C9NPC1RIPK2 | |
| SCHEMBL12818485 | 0.79 | PDE3B (0.39) | PDE3BPDE3ACYP2C9NPC1RIPK2 | |
| SCHEMBL12818373 | 0.78 | SMN1; SMN2 (0.42) | PDE3BPDE3ACYP2C9MEN1KMT2A | |
| SCHEMBL1817818 | 0.77 | CYP11B1 (0.45) | PDE3BPDE3ACYP2C9NPC1RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011057892-A1 | 2,3-DIHYDROBENZOXAZINE AND 2,3-DIHYDROBENZOTHIAZINE DERIVATES AS HIF-INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | ELARA PHARMACEUTICALS GMBH (DE) | 2011-05-19 | — | — | WO | claimed |
| WO-2011057892-A1 | 2,3-DIHYDROBENZOXAZINE AND 2,3-DIHYDROBENZOTHIAZINE DERIVATES AS HIF-INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | ELARA PHARMACEUTICALS GMBH (DE) | 2011-05-19 | — | — | WO | disclosed |