Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 8/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18172576 | 1.00 | KDM1A (0.60) | KDM1AKDM4EPKMTGFBR1STS | |
| SCHEMBL18172681 | 0.89 | KDM4E (0.55) | KDM1AKDM4EPKMTGFBR1STS | |
| SCHEMBL18172678 | 0.89 | KDM4E (0.55) | KDM1AKDM4EPKMTGFBR1STS | |
| SCHEMBL18172886 | 0.89 | KDM4E (0.54) | KDM1AKDM4EPKMTGFBR1STS | |
| SCHEMBL18172884 | 0.89 | KDM4E (0.54) | KDM1AKDM4EPKMTGFBR1STS | |
| SCHEMBL18172892 | 0.89 | KDM4E (0.54) | KDM1AKDM4EPKMTGFBR1STS | |
| SCHEMBL18172889 | 0.89 | KDM4E (0.54) | KDM1AKDM4EPKMTGFBR1STS | |
| SCHEMBL18173072 | 0.85 | KDM1A (0.56) | KDM1AKDM4EPKM | |
| SCHEMBL20527397 | 0.85 | KDM1A (0.56) | KDM1AKDM4EPKM | |
| SCHEMBL18173076 | 0.85 | KDM1A (0.56) | KDM1AKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286172-A1 | LSD1 INHIBITORS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172496-A1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2016-10-27 | — | — | WO | disclosed |