Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9447837 | 1.00 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8958237 | 1.00 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8958557 | 1.00 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8958401 | 1.00 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL8958406 | 0.97 | SMN1; SMN2 (0.48) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL23412771 | 0.93 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17144002 | 0.91 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| Triethylene Glycol SCHEMBL9447836 | 0.91 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL23636435 | 0.91 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL22022676 | 0.91 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133337-A1 | CALICHEAMICIN CONSTRUCTS AND METHODS OF USE | ABBVIE STEMCENTRX LLC (US) | 2018-05-17 | — | — | US | disclosed |
| EP-3285807-A1 | CALICHEAMICIN CONSTRUCTS AND METHODS OF USE | Abbvie Stemcentrx LLC (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172273-A1 | CALICHEAMICIN CONSTRUCTS AND METHODS OF USE | STEM CENTRX, INC. (US) | 2016-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133337-A1 | CALICHEAMICIN CONSTRUCTS AND METHODS OF USE | CALD1, CALR, CLSPN | MEN1 3748/4885KMT2A 3572/4885SMN1; SMN2 4630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.