Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.44 |
| ▸ | SCN4A | P35499 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 5/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | LYN | P07948 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27934510 | 1.00 | BTK (0.44) | BTKSCN4ALCKSRCLYN | |
| SCHEMBL27959668 | 0.93 | LCK (0.47) | BTKSCN4ALCKSRCNPC1 | |
| SCHEMBL5804770 | 0.93 | LCK (0.47) | BTKSCN4ALCKSRCNPC1 | |
| SCHEMBL15563203 | 0.88 | BTK (0.42) | BTKSCN4ALCKLYNEGFR | |
| SCHEMBL27577918 | 0.87 | SCN4A (0.49) | BTKSCN4ALCKSRCNPC1 | |
| SCHEMBL27934497 | 0.87 | EGFR (0.45) | BTKSCN4ALCKLYNEGFR | |
| SCHEMBL7047879 | 0.85 | SCN4A (0.47) | BTKSCN4ALCKSRCNPC1 | |
| SCHEMBL19210389 | 0.84 | TNK2 (0.40) | BTKLCKSRCLYNEGFR | |
| SCHEMBL22720878 | 0.81 | SCN4A (0.42) | BTKSCN4ALCKSRCLYN | |
| SCHEMBL28375318 | 0.81 | BTK (0.40) | BTKLCKLYNEGFRBLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016170545-A1 | PROCESS FOR THE PREPARATION OF 1-[(3R)-3-[4-AMINO-3-(4-PHENOXYPHENVL)-1H- PVRAZOLO[3,4-D]PYRINIIDIN-1-Y1]-1-PIPERIDINVL]-2-PROPEN-1-ONE AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2016-10-27 | — | — | WO | claimed |
| CN-116745268-A | Benzenesulfonamide derivatives and uses thereof | 2692372安大略公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-115322226-B | Covalent targeting arsenic inhibitor and preparation method and application thereof | 厦门大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-115746000-A | Compounds and methods for modulating bruton's tyrosine kinase | 嘉兴和剂药业有限公司 | 2023-03-07 | — | — | CN | disclosed |
| CN-115322226-A | Covalent targeting arsenic inhibitor and preparation method and application thereof | 厦门大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-109071455-B | Compounds and methods for modulating bruton's tyrosine kinase | 嘉兴和剂药业有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-105399756-B | BTK inhibitor and application thereof | 广东东阳光药业有限公司 | 2019-06-25 | — | — | CN | disclosed |
| WO-2016170545-A1 | PROCESS FOR THE PREPARATION OF 1-[(3R)-3-[4-AMINO-3-(4-PHENOXYPHENVL)-1H- PVRAZOLO[3,4-D]PYRINIIDIN-1-Y1]-1-PIPERIDINVL]-2-PROPEN-1-ONE AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2016-10-27 | — | — | WO | disclosed |