Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.52 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ATR | Q13535 | 1/20 | 0.52 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.52 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14239909 | 0.89 | MTOR (0.57) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL14239908 | 0.88 | PIK3CA (0.56) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL18174465 | 0.88 | MTOR (0.56) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL14239225 | 0.87 | MTOR (0.57) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL18174469 | 0.87 | MTOR (0.54) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL14239571 | 0.84 | MTOR (0.55) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL14239905 | 0.84 | MTOR (0.52) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL14239226 | 0.84 | PIK3CA (0.57) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL14239570 | 0.83 | MTOR (0.61) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B | |
| SCHEMBL14239228 | 0.83 | PIK3CA (0.69) | MTORPIK3CAPIK3CDPIK3C2APIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9475812-B2 | Pyridonaphthyridine type dual PI3K and mTOR inhibitor and its preparation and use | Xuanzhu Pharma Co., Ltd. (CN) | 2016-10-25 | — | — | US | disclosed |