Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18174823 | 0.95 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL18174821 | 0.92 | BACE1 (0.56) | BACE1BACE2 | |
| SCHEMBL18174825 | 0.90 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL18174826 | 0.90 | BACE1 (0.45) | BACE1BACE2 | |
| SCHEMBL10328883 | 0.88 | BACE1 (0.59) | BACE1BACE2 | |
| SCHEMBL10328897 | 0.88 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL18174828 | 0.88 | BACE1 (0.44) | BACE1BACE2 | |
| SCHEMBL18174822 | 0.87 | BACE1 (0.52) | BACE1BACE2 | |
| SCHEMBL18174816 | 0.87 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL15892967 | 0.86 | BACE1 (0.57) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9475785-B2 | Iminothiadiazine dioxide compounds as BACE inhibitors, compositions and their use | MERCK SHARP & DOHME CORP. (US) | 2016-10-25 | — | — | US | disclosed |