Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.81 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.81 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | PLD2 | O14939 | 15/20 | 0.39 |
| ▸ | PLD1 | Q13393 | 14/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798610 | 0.91 | PIK3CD (0.81) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL788077 | 0.91 | PIK3CD (0.81) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL787981 | 0.89 | PIK3CD (1.00) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL798747 | 0.87 | PIK3CD (0.82) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL788700 | 0.87 | PIK3CD (0.81) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL806210 | 0.85 | PIK3CD (0.91) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL788134 | 0.84 | PIK3CD (0.90) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL10227555 | 0.84 | PIK3CD (0.81) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL793844 | 0.82 | PIK3CD (0.67) | PIK3CDPIK3R1PDE2APDE4APIK3CA | |
| SCHEMBL788338 | 0.82 | PIK3CD (0.87) | PIK3CDPIK3R1PDE2APDE4APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616469-B1 | 9H-PURINE COMPOUNDS AS PI3K-DELTA INHIBITORS AND METHODS FOR THEIR MANUFACTURE | EXELIXIS INC (US) | 2016-10-26 | — | — | EP | disclosed |