Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.44 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.44 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.37 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.37 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3859 | 0.94 | LPAR1 (0.51) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL4624 | 0.90 | LPAR1 (0.44) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL9559 | 0.87 | LPAR1 (0.44) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL4662 | 0.84 | LPAR1 (0.53) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL9558 | 0.83 | LPAR1 (0.40) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL4423 | 0.82 | CYP11B1 (0.37) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL4498 | 0.82 | LPAR1 (0.54) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL4757 | 0.80 | LPAR1 (0.46) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL4561 | 0.79 | ABCC3 (0.46) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL10029 | 0.78 | LPAR1 (0.46) | LPAR1ABCC3ABCC4ABCB11CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483251-B1 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2016-10-26 | — | — | EP | disclosed |