Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 6/20 | 0.41 |
| ▸ | SYK | P43405 | 6/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | SERPINA2 | P20848 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16489038 | 0.84 | ATR (0.41) | ATRSYKSCN10ASCN2AJAK2 | |
| SCHEMBL18180887 | 0.84 | ATR (0.59) | ATRSYKJAK2ABL1KIT | |
| SCHEMBL18177406 | 0.81 | SCN2A (0.38) | ATRSCN10ASCN2APIK3CAMTOR | |
| SCHEMBL18177400 | 0.80 | ATR (0.53) | ATRSYKSCN10ASCN2AJAK2 | |
| SCHEMBL18177386 | 0.80 | ATR (0.41) | ATRSYKSCN10ASCN2AJAK2 | |
| SCHEMBL18177413 | 0.79 | ATR (0.41) | ATRSYKSCN10ASCN2AJAK2 | |
| SCHEMBL18177408 | 0.79 | NAMPT (0.42) | — | |
| SCHEMBL16489035 | 0.76 | ATR (0.34) | ATRSCN10ASCN2A | |
| SCHEMBL17826209 | 0.75 | ATR (0.41) | ATRSYKJAK2ABL1KIT | |
| SCHEMBL18177391 | 0.75 | ATR (0.48) | ATRSYKSCN10ASCN2AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160311809-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311809-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K5 | ATR 1/4885SYK 574/4885SCN10A 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.