Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 3/20 | 0.87 |
| ▸ | NAA50 | Q9GZZ1 | 2/20 | 0.87 |
| ▸ | CHAT | P28329 | 2/20 | 0.87 |
| ▸ | AURKA | O14965 | 2/20 | 0.87 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.87 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.87 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18812306 | 1.00 | EP300 (0.87) | EP300NAA50CHATAURKAKAT5 | |
| SCHEMBL9945414 | 0.96 | EP300 (0.91) | EP300NAA50CHATAURKAKAT5 | |
| SCHEMBL19704092 | 0.96 | EP300 (0.91) | EP300NAA50CHATAURKAKAT5 | |
| SCHEMBL18803179 | 0.96 | EP300 (0.91) | EP300NAA50CHATAURKAKAT5 | |
| SCHEMBL18803180 | 0.94 | EP300 (0.86) | EP300NAA50CHATAURKAKAT5 | |
| SCHEMBL16856171 | 0.94 | EP300 (0.86) | EP300NAA50CHATAURKAKAT5 | |
| SCHEMBL18818076 | 0.94 | EP300 (0.83) | EP300NAA50CHATAURKAKAT5 | |
| SCHEMBL14769751 | 0.94 | EP300 (0.88) | EP300NAA50CHATAURKAKAT5 | |
| SCHEMBL14124844 | 0.94 | EP300 (0.88) | EP300NAA50CHATAURKAKAT5 | |
| SCHEMBL22810980 | 0.94 | EP300 (0.89) | EP300NAA50CHATAURKAKAT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753578-A1 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | Novartis AG (CH) | 2020-12-23 | — | — | EP | disclosed |
| US-10787480-B2 | Cytotoxic peptides and conjugates thereof | NOVARTIS AG (CH) | 2020-09-29 | — | — | US | disclosed |
| US-10392421-B2 | Cytotoxic peptides and conjugates thereof | NOVARTIS AG (CH) | 2019-08-27 | — | — | US | disclosed |
| US-9988420-B2 | Cytotoxic peptides and conjugates thereof | NOVARTIS AG (CH) | 2018-06-05 | — | — | US | disclosed |
| US-20160311853-A1 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787480-B2 | Cytotoxic peptides and conjugates thereof | CD47, NGLY1, VIP | EP300 4723/4885NAA50 4456/4885CHAT 3634/4885 |
| US-10392421-B2 | Cytotoxic peptides and conjugates thereof | CD47, NGLY1, VIP | EP300 4723/4885NAA50 4456/4885CHAT 3634/4885 |
| US-20160311853-A1 | CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF | CD47, NGLY1, VIP | EP300 4723/4885NAA50 4456/4885CHAT 3634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.