Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.74 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.60 |
| ▸ | EGFR | P00533 | 6/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19920273 | 0.88 | ALK (0.72) | ALKPTK2EGFRMET | |
| SCHEMBL18181710 | 0.88 | ALK (0.78) | ALKPTK2EGFRMET | |
| SCHEMBL29846385 | 0.88 | ALK (0.70) | ALKPTK2EGFRMET | |
| SCHEMBL18181717 | 0.85 | ALK (1.00) | ALKPTK2EGFRMET | |
| SCHEMBL18181701 | 0.83 | ALK (0.64) | ALKPTK2EGFRMET | |
| SCHEMBL29846346 | 0.83 | ALK (0.71) | ALKPTK2EGFRMET | |
| SCHEMBL18181621 | 0.83 | ALK (0.71) | ALKPTK2EGFRMET | |
| SCHEMBL29846365 | 0.83 | ALK (0.64) | ALKPTK2EGFRMET | |
| SCHEMBL18181711 | 0.80 | ALK (1.00) | ALKPTK2EGFRMET | |
| SCHEMBL18181661 | 0.79 | ALK (1.00) | ALKEGFRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016169504-A1 | CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF | 广州再极医药科技有限公司 | 2016-10-27 | — | — | WO | disclosed |