⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL10399935 | 0.86 | — | — | |
| SCHEMBL7209689 | 0.86 | — | — | |
| Lithium Ion SCHEMBL3393433 | 0.86 | — | — | |
| SCHEMBL11285652 | 0.86 | — | — | |
| Potassium Ion SCHEMBL11290501 | 0.86 | — | — | |
| SCHEMBL15709602 | 0.86 | — | — | |
| Silver SCHEMBL2528465 | 0.86 | — | — | |
| SCHEMBL17008162 | 0.86 | — | — | |
| SCHEMBL1407929 | 0.46 | — | — | |
| SCHEMBL10340103 | 0.44 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220513-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-01-11 | — | — | US | claimed |
| US-20210009605-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-01-14 | — | — | US | claimed |
| US-10344038-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-09 | — | — | US | claimed |
| WO-2016176560-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-03 | — | — | WO | claimed |
| US-11220513-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-01-11 | — | — | US | disclosed |
| US-20210009605-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-01-14 | — | — | US | disclosed |
| US-10633392-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-04-28 | — | — | US | disclosed |
| US-20200031843-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-01-30 | — | — | US | disclosed |
| US-10344038-B2 | Chromium-mediated coupling and application to the synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-09 | — | — | US | disclosed |
| WO-2016176560-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-03 | — | — | WO | disclosed |