Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 17/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18192977 | 0.92 | TYK2 (0.45) | TYK2STAT3CCNE1CDK2FLT3 | |
| SCHEMBL18192966 | 0.91 | TYK2 (0.47) | TYK2STAT3CDK2PDE4D | |
| SCHEMBL18193007 | 0.91 | TYK2 (0.44) | TYK2STAT3PDE4D | |
| SCHEMBL18192950 | 0.86 | TYK2 (0.48) | TYK2STAT3PDE4D | |
| SCHEMBL18192981 | 0.86 | TYK2 (0.41) | TYK2STAT3PDE4D | |
| SCHEMBL13062313 | 0.85 | TYK2 (0.45) | TYK2CCNE1CDK2FLT3PDE4D | |
| SCHEMBL3781609 | 0.85 | TYK2 (0.50) | TYK2STAT3PDE4D | |
| SCHEMBL18192992 | 0.84 | TYK2 (0.45) | TYK2STAT3PDE4D | |
| SCHEMBL18192999 | 0.84 | TYK2 (0.44) | TYK2STAT3PDE4D | |
| SCHEMBL18193006 | 0.84 | TYK2 (0.46) | TYK2STAT3CCNE1CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240488-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-02 | — | — | EP | claimed |