Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18192969 | 0.96 | TYK2 (0.43) | TYK2STAT3PDE4DTTKIRAK4 | |
| SCHEMBL18192984 | 0.96 | TYK2 (0.43) | TYK2STAT3PDE4DTTKIRAK4 | |
| SCHEMBL18192951 | 0.94 | TYK2 (0.45) | TYK2STAT3PDE4DTTKIRAK4 | |
| SCHEMBL18192999 | 0.93 | TYK2 (0.44) | TYK2STAT3PDE4DTTKIRAK4 | |
| SCHEMBL18192988 | 0.91 | TYK2 (0.42) | TYK2STAT3PDE4DTTK | |
| SCHEMBL18192985 | 0.91 | TYK2 (0.43) | TYK2STAT3PDE4D | |
| SCHEMBL18192920 | 0.90 | TYK2 (0.44) | TYK2STAT3PDE4DTTKIRAK4 | |
| SCHEMBL18192948 | 0.90 | TYK2 (0.44) | TYK2STAT3PDE4DTTKIRAK4 | |
| SCHEMBL18192950 | 0.90 | TYK2 (0.48) | TYK2STAT3PDE4DTTK | |
| SCHEMBL18192953 | 0.90 | TYK2 (0.44) | TYK2STAT3PDE4DTTKIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240488-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-02 | — | — | EP | claimed |