Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.46 |
| ▸ | CACNG8 | Q8WXS5 | 6/20 | 0.46 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189551 | 0.80 | GRIA1 (0.55) | GRIA1CACNG8CACNG2AHRPGR | |
| SCHEMBL18189614 | 0.76 | GRIA1 (0.77) | GRIA1CACNG8CACNG2AHRPGR | |
| SCHEMBL18189330 | 0.74 | GRIA1 (0.49) | GRIA1CACNG8CACNG2AHRPGR | |
| SCHEMBL18189533 | 0.73 | GRIA1 (0.47) | GRIA1CACNG8CACNG2TDP2 | |
| SCHEMBL18189624 | 0.72 | GRIA1 (0.55) | GRIA1CACNG8CACNG2AHRPGR | |
| SCHEMBL18189388 | 0.71 | GRIA1 (0.60) | GRIA1CACNG8CACNG2AHRPGR | |
| SCHEMBL18189394 | 0.70 | GRIA1 (0.60) | GRIA1CACNG8CACNG2AHRPGR | |
| SCHEMBL18189335 | 0.70 | GRIA1 (0.60) | GRIA1CACNG8CACNG2AHRPGR | |
| SCHEMBL18189381 | 0.69 | GRIA1 (0.49) | GRIA1CACNG8CACNG2AHRPGR | |
| SCHEMBL18189528 | 0.68 | GRIA1 (0.69) | GRIA1CACNG8CACNG2AHRPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016176463-A1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-03 | — | — | WO | disclosed |