Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1820300 | 0.89 | MEN1 (0.42) | KMT2AMEN1MAPTTP53PDE3B | |
| SCHEMBL1817728 | 0.84 | KMT2A (0.41) | KMT2AMEN1MAPTTP53PDE3B | |
| SCHEMBL1819765 | 0.83 | MEN1 (0.43) | KMT2AMEN1MAPTTP53PDE3B | |
| SCHEMBL12818152 | 0.83 | MEN1 (0.38) | KMT2AMEN1MAPTTP53PDE3B | |
| SCHEMBL1818993 | 0.82 | KMT2A (0.40) | KMT2AMEN1MAPTTP53PDE3B | |
| SCHEMBL1818415 | 0.81 | KMT2A (0.39) | KMT2AMEN1MAPTTP53PDE3B | |
| SCHEMBL1821031 | 0.80 | KMT2A (0.41) | KMT2AMEN1MAPTTP53PDE3B | |
| SCHEMBL1819574 | 0.80 | KMT2A (0.41) | KMT2AMEN1MAPTTP53PDE3B | |
| SCHEMBL1818795 | 0.80 | KMT2A (0.40) | KMT2AMEN1MAPTTP53PDE3B | |
| SCHEMBL1818416 | 0.80 | KMT2A (0.44) | KMT2AMEN1MAPTTP53PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011057892-A1 | 2,3-DIHYDROBENZOXAZINE AND 2,3-DIHYDROBENZOTHIAZINE DERIVATES AS HIF-INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | ELARA PHARMACEUTICALS GMBH (DE) | 2011-05-19 | — | — | WO | claimed |
| WO-2011057892-A1 | 2,3-DIHYDROBENZOXAZINE AND 2,3-DIHYDROBENZOTHIAZINE DERIVATES AS HIF-INHIBITORS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | ELARA PHARMACEUTICALS GMBH (DE) | 2011-05-19 | — | — | WO | disclosed |