Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 20/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11909105 | 0.97 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203454 | 0.88 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203516 | 0.87 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1 | |
| SCHEMBL18169542 | 0.87 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203481 | 0.87 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1 | |
| SCHEMBL11908793 | 0.86 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203291 | 0.83 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1 | |
| SCHEMBL11908150 | 0.82 | HSP90AA1 (0.77) | HSP90AA1HSP90AB1 | |
| SCHEMBL1669387 | 0.80 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1 | |
| SCHEMBL1670397 | 0.79 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091019-B1 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | SLOAN KETTERING INST CANCER RES (US) | 2019-04-03 | — | — | EP | disclosed |
| EP-3091019-A2 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | Sloan Kettering Institute For Cancer Research (US) | 2016-11-09 | — | — | EP | disclosed |