Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18205190 | 1.00 | CYP2D6 (0.47) | CYP2D6SMN1; SMN2ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL18212465 | 0.87 | CYP2D6 (0.37) | CYP2D6SMN1; SMN2ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL4323995 | 0.82 | CYP2D6 (0.35) | CYP2D6SMN1; SMN2 | |
| SCHEMBL14706855 | 0.81 | CYP2D6 (0.66) | CYP2D6SMN1; SMN2ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL1043849 | 0.80 | PIK3CD (0.39) | CYP2D6ALDH1A1CYP3A4MAPK1TSHR | |
| SCHEMBL6680924 | 0.80 | — | — | |
| SCHEMBL4328970 | 0.79 | CYP2D6 (0.36) | CYP2D6SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL4420326 | 0.78 | CYP2D6 (0.34) | CYP2D6SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL18926689 | 0.78 | CYP2D6 (0.68) | CYP2D6SMN1; SMN2ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL23885878 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3291810-B1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2022-08-10 | — | — | EP | disclosed |
| US-20190202795-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2019-07-04 | — | — | US | disclosed |
| US-10053434-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2018-08-21 | — | — | US | disclosed |
| US-20160326124-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2016-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190202795-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | HDAC1, HDAC7, HDAC5 | CYP2D6 3895/4885SMN1; SMN2 3271/4885ALDH1A1 559/4885 |
| US-10053434-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | HDAC1, HDAC7, HDAC5 | CYP2D6 3895/4885SMN1; SMN2 3271/4885ALDH1A1 559/4885 |
| US-20160326124-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | HDAC1, HDAC7, HDAC5 | CYP2D6 3895/4885SMN1; SMN2 3271/4885ALDH1A1 559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.