Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911585 | 0.83 | EPHX2 (0.41) | EPHX2DDB1CRBNKEAP1KCNH2 | |
| SCHEMBL18948132 | 0.80 | EPHX2 (0.39) | EPHX2DDB1CRBNKEAP1KCNH2 | |
| SCHEMBL324166 | 0.76 | — | — | |
| SCHEMBL12391740 | 0.76 | DDB1 (0.41) | EPHX2DDB1CRBNKCNH2GRIN2B | |
| SCHEMBL12384367 | 0.72 | EPHX2 (0.42) | EPHX2DDB1CRBNKEAP1KCNH2 | |
| SCHEMBL16768701 | 0.72 | EPHX2 (0.43) | EPHX2DDB1CRBNKCNH2GRIN2B | |
| SCHEMBL12935909 | 0.72 | MAPT (0.46) | EPHX2KDM4EALDH1A1LMNAHTT | |
| SCHEMBL21025681 | 0.71 | CYP19A1 (0.38) | EPHX2DDB1CRBNKEAP1KCNH2 | |
| SCHEMBL21202232 | 0.71 | TSHR (0.38) | EPHX2DDB1CRBNKDM4EALDH1A1 | |
| SCHEMBL17788638 | 0.71 | EPHX2 (0.49) | EPHX2DDB1CRBNKCNH2GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016177686-A1 | PYRIDAZINE DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-11-10 | — | — | WO | disclosed |