Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.31 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18217193 | 0.90 | APP (0.32) | APPERCC5FEN1 | |
| SCHEMBL20182371 | 0.87 | — | — | |
| SCHEMBL21241758 | 0.85 | APP (0.33) | APPERCC5FEN1 | |
| SCHEMBL19799086 | 0.84 | APP (0.32) | APPERCC5FEN1 | |
| SCHEMBL16265228 | 0.82 | APP (0.36) | APPERCC5FEN1 | |
| SCHEMBL21134088 | 0.78 | APP (0.33) | APPERCC5FEN1 | |
| SCHEMBL16546543 | 0.77 | APP (0.30) | APP | |
| SCHEMBL16546558 | 0.76 | — | — | |
| SCHEMBL16546542 | 0.76 | — | — | |
| SCHEMBL25070566 | 0.75 | APP (0.46) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738240-B2 | Thiadiazoloquinoxaline derivatives | MERCK PATENT GMBH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| WO-2016177449-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-11-10 | — | — | WO | disclosed |