Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.37 |
| ▸ | CDK9 | P50750 | 4/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23925070 | 0.93 | EGFR (0.53) | EGFRMKNK2CCNT1CDK9MKNK1 | |
| SCHEMBL18202243 | 0.92 | EGFR (0.58) | EGFRMKNK2CCNT1CDK9MKNK1 | |
| SCHEMBL18202224 | 0.85 | EGFR (0.52) | EGFRMKNK2CCNT1CDK9CCNA2 | |
| SCHEMBL19921246 | 0.85 | EGFR (0.50) | EGFRMKNK2CCNT1CDK9CCNA2 | |
| SCHEMBL18202235 | 0.84 | EGFR (0.49) | EGFRMKNK2CCNT1CDK9CCNA2 | |
| SCHEMBL18202177 | 0.81 | EGFR (0.46) | EGFRMKNK2CCNT1CDK9MKNK1 | |
| SCHEMBL18202145 | 0.81 | EGFR (0.51) | EGFRMKNK2CCNT1CDK9CCNA2 | |
| SCHEMBL18202359 | 0.81 | EGFR (0.45) | EGFRMKNK2CCNT1CDK9MKNK1 | |
| SCHEMBL18202368 | 0.81 | EGFR (0.60) | EGFRMKNK2 | |
| SCHEMBL18202334 | 0.80 | EGFR (0.73) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294712-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ARIAD Pharmaceuticals, Inc. (US) | 2018-03-21 | — | — | EP | disclosed |
| WO-2016183278-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ARIAD PHARMACEUTICALS, INC. (US) | 2016-11-17 | — | — | WO | disclosed |