Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 20/20 | 1.00 |
| ▸ | PTPN6 | P29350 | 9/20 | 0.67 |
| ▸ | PTPN11 | Q06124 | 9/20 | 0.67 |
| ▸ | PTPRC | P08575 | 8/20 | 0.67 |
| ▸ | PTPN2 | P17706 | 8/20 | 0.67 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.67 |
| ▸ | PTPN9 | P43378 | 8/20 | 0.67 |
| ▸ | DUSP3 | P51452 | 8/20 | 0.67 |
| ▸ | PTPRG | P23470 | 4/20 | 0.67 |
| ▸ | ACP1 | P24666 | 4/20 | 0.67 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.67 |
| ▸ | PTPN13 | Q12923 | 4/20 | 0.67 |
| ▸ | PTPRB | P23467 | 2/20 | 0.67 |
| ▸ | PTPN3 | P26045 | 2/20 | 0.67 |
| ▸ | PTPRM | P28827 | 2/20 | 0.67 |
| ▸ | PTPN12 | Q05209 | 2/20 | 0.67 |
| ▸ | DUSP23 | Q9BVJ7 | 2/20 | 0.67 |
| ▸ | DUSP15 | Q9H1R2 | 2/20 | 0.67 |
| ▸ | EPM2A | O95278 | 2/20 | 0.45 |
| ▸ | DUSP22 | Q9NRW4 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15829192 | 0.95 | PTPN22 (0.90) | PTPN22PTPN6PTPN11PTPRCPTPN2 | |
| SCHEMBL15829188 | 0.82 | PTPN22 (1.00) | PTPN22PTPN6PTPN11PTPRCPTPN2 | |
| SCHEMBL13736685 | 0.80 | PTPN22 (1.00) | PTPN22PTPN6PTPN11PTPRCPTPN2 | |
| SCHEMBL15829190 | 0.77 | PTPN22 (1.00) | PTPN22PTPN6PTPN11PTPRCPTPN2 | |
| SCHEMBL15829189 | 0.76 | PTPN22 (1.00) | PTPN22PTPN6PTPN11PTPRCPTPN2 | |
| SCHEMBL15829191 | 0.76 | PTPN22 (1.00) | PTPN22PTPN6PTPN11PTPRCPTPN2 | |
| SCHEMBL18230879 | 0.75 | PTPN22 (1.00) | PTPN22PTPN6PTPN11PTPRCPTPN2 | |
| SCHEMBL15829185 | 0.75 | PTPN22 (1.00) | PTPN22PTPN6PTPN11PTPRCPTPN2 | |
| SCHEMBL15829193 | 0.74 | PTPN22 (0.84) | PTPN22PTPN6PTPN11PTPRCPTPN2 | |
| SCHEMBL18230880 | 0.72 | PTPN22 (1.00) | PTPN22PTPN6PTPN11PTPRCPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493436-B2 | Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-9493436-B2 | Tyrosine phosphatase inhibitors and uses thereof to modulate the activity of enzymes involved in the pathology of Mycobacterium tuberculosis | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |