Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.76 |
| ▸ | BLK | P51451 | 2/20 | 0.75 |
| ▸ | ITK | Q08881 | 2/20 | 0.75 |
| ▸ | FGR | P09769 | 1/20 | 0.75 |
| ▸ | FLT3 | P36888 | 1/20 | 0.75 |
| ▸ | CSK | P41240 | 1/20 | 0.75 |
| ▸ | JAK3 | P52333 | 1/20 | 0.75 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20177356 | 1.00 | BTK (0.76) | BTKBLKITKFGRFLT3 | |
| SCHEMBL20177257 | 0.95 | BTK (0.76) | BTKBLKITKFGRFLT3 | |
| SCHEMBL20177246 | 0.95 | BTK (0.76) | BTKBLKITKFGRFLT3 | |
| SCHEMBL29671300 | 0.92 | BTK (0.81) | BTKBLKITKFGRFLT3 | |
| SCHEMBL15641034 | 0.92 | BTK (0.81) | BTKBLKITKFGRFLT3 | |
| SCHEMBL30324920 | 0.92 | BTK (0.81) | BTKBLKITKFGRFLT3 | |
| SCHEMBL1628863 | 0.92 | BTK (0.81) | BTKBLKITKFGRFLT3 | |
| SCHEMBL12808088 | 0.92 | BTK (0.81) | BTKBLKITKFGRFLT3 | |
| SCHEMBL21338869 | 0.91 | BTK (0.76) | BTKBLKITKFGRFLT3 | |
| SCHEMBL24197246 | 0.91 | BTK (0.71) | BTKBLKITKFGRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016180334-A1 | DUAL-SITE IRREVERSIBLE BRUTON'S TYROSINE KINASE INHIBITOR, COMPOSITION AND APPLICATION THEREFOF | 杭州和正医药有限公司 | 2016-11-17 | — | — | WO | disclosed |