⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31703968 | 0.87 | USP2 (0.52) | — | |
| SCHEMBL27377541 | 0.84 | USP2 (0.42) | — | |
| SCHEMBL21870638 | 0.79 | USP2 (0.41) | — | |
| SCHEMBL21614238 | 0.78 | — | — | |
| SCHEMBL4222977 | 0.76 | — | — | |
| SCHEMBL241536 | 0.75 | — | — | |
| SCHEMBL23637739 | 0.73 | USP2 (0.44) | — | |
| SCHEMBL14844878 | 0.73 | — | — | |
| SCHEMBL25009076 | 0.71 | USP2 (0.41) | — | |
| SCHEMBL13167376 | 0.71 | NAMPT (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713307-B2 | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases | CHEMOCENTRYX, INC. (US) | 2023-08-01 | — | — | US | disclosed |
| EP-3573986-B1 | BICYCLIC BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION | UCB Biopharma SRL (BE) | 2021-05-26 | — | — | EP | disclosed |
| US-20160333009-A1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |