Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20088845 | 0.81 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18237054 | 0.77 | HDAC6 (0.95) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL21976948 | 0.77 | NPC1 (0.68) | MAPTMAPK1RAB9AMEN1KMT2A | |
| SCHEMBL20088774 | 0.77 | HDAC6 (0.64) | HDAC6MAPTRAB9AHDAC3HDAC1 | |
| SCHEMBL20088905 | 0.76 | HDAC6 (0.74) | HDAC6RAB9AHDAC3HDAC1HDAC8 | |
| SCHEMBL18229669 | 0.75 | HDAC6 (0.79) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18229509 | 0.75 | HDAC6 (1.00) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18237041 | 0.75 | HDAC6 (0.76) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18229729 | 0.75 | HDAC6 (0.62) | HDAC6HDAC3HDAC1HDAC8HDAC2 | |
| SCHEMBL18229641 | 0.75 | HDAC6 (0.65) | HDAC6HDAC3HDAC1HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | claimed |
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | disclosed |
| US-20180110755-A1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2018-04-26 | — | — | US | disclosed |
| WO-2016180472-A1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2016-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180110755-A1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | HDAC6, HDAC1, HDAC11 | HDAC6 1/4885MAPT 463/4885MAPK1 1116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.