Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.45 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 3/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16945218 | 1.00 | KIT (0.46) | KITMAP3K7TAB1AAK1CLK1 | |
| SCHEMBL16945244 | 0.91 | MAP3K7 (0.56) | MAP3K7TAB1DYRK1ACLK2CLK4 | |
| SCHEMBL18238700 | 0.91 | MAP3K7 (0.56) | MAP3K7TAB1DYRK1ACLK2CLK4 | |
| SCHEMBL18250572 | 0.90 | KIT (0.46) | KITAAK1CLK1DYRK1ADYRK2 | |
| SCHEMBL16932979 | 0.86 | KIT (0.55) | KITMAP3K7TAB1AAK1DYRK1A | |
| SCHEMBL16932982 | 0.86 | KIT (0.55) | KITMAP3K7TAB1AAK1DYRK1A | |
| SCHEMBL16949130 | 0.83 | MAP3K7 (0.43) | KITMAP3K7TAB1AAK1CLK1 | |
| SCHEMBL18238903 | 0.83 | MAP3K7 (0.43) | KITMAP3K7TAB1AAK1CLK1 | |
| SCHEMBL16945263 | 0.82 | MAP3K7 (0.54) | KITMAP3K7TAB1DYRK1ACLK2 | |
| SCHEMBL18238686 | 0.82 | MAP3K7 (0.54) | KITMAP3K7TAB1DYRK1ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |