Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 2/20 | 0.50 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16945204 | 1.00 | PLCG1 (0.50) | PLCG1MAP3K11MKNK1MKNK2KIT | |
| SCHEMBL18250496 | 0.90 | PLCG1 (0.51) | PLCG1MAP3K11MKNK1MKNK2KIT | |
| SCHEMBL18250478 | 0.89 | MAP3K7 (0.43) | PLCG1MAP3K11DYRK1AAXLPIK3CA | |
| SCHEMBL18238121 | 0.89 | MAP3K7 (0.51) | PLCG1MAP3K11DYRK1AAAK1AXL | |
| SCHEMBL16945156 | 0.89 | MAP3K7 (0.51) | PLCG1MAP3K11DYRK1AAAK1AXL | |
| SCHEMBL16932979 | 0.88 | KIT (0.55) | MAP3K11KITDYRK1AAAK1AXL | |
| SCHEMBL16932982 | 0.88 | KIT (0.55) | MAP3K11KITDYRK1AAAK1AXL | |
| SCHEMBL18250479 | 0.88 | MAP3K7 (0.52) | PLCG1MAP3K11DYRK1AAXLSGK1 | |
| SCHEMBL16949124 | 0.87 | MAP3K11 (0.43) | PLCG1MAP3K11DYRK1AAXLPIK3CA | |
| SCHEMBL16948961 | 0.87 | PLCG1 (0.52) | PLCG1MAP3K11KITDYRK1AAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |