Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 11/20 | 0.60 |
| ▸ | TAB1 | Q15750 | 11/20 | 0.60 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16948919 | 1.00 | MAP3K7 (0.60) | MAP3K7TAB1CAMKK2MEN1NPC1 | |
| SCHEMBL18238700 | 0.89 | MAP3K7 (0.56) | MAP3K7TAB1CAMKK2AXLCDC7 | |
| SCHEMBL16945244 | 0.89 | MAP3K7 (0.56) | MAP3K7TAB1CAMKK2AXLCDC7 | |
| SCHEMBL18238686 | 0.87 | MAP3K7 (0.54) | MAP3K7TAB1CAMKK2AXLCDC7 | |
| SCHEMBL16945263 | 0.87 | MAP3K7 (0.54) | MAP3K7TAB1CAMKK2AXLCDC7 | |
| SCHEMBL16945221 | 0.84 | MAP3K7 (0.53) | MAP3K7TAB1CAMKK2AXLCDC7 | |
| SCHEMBL18238809 | 0.84 | MAP3K7 (0.53) | MAP3K7TAB1CAMKK2AXLCDC7 | |
| SCHEMBL4348312 | 0.83 | PRKD3 (0.56) | MAP3K7TAB1MEN1NPC1RAB9A | |
| SCHEMBL4348302 | 0.83 | PRKD3 (0.56) | MAP3K7TAB1MEN1NPC1RAB9A | |
| SCHEMBL16932960 | 0.82 | GSK3B (0.56) | MAP3K7TAB1CAMKK2AXLCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |