Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 3/20 | 0.44 |
| ▸ | SGK1 | O00141 | 3/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | ITK | Q08881 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16949119 | 1.00 | MAP3K11 (0.44) | MAP3K11KITAXLSGK1CAMKK2 | |
| SCHEMBL18238746 | 0.92 | MAP3K11 (0.44) | MAP3K11KITAXLSGK1CAMKK2 | |
| SCHEMBL16948749 | 0.92 | MAP3K11 (0.44) | MAP3K11KITAXLSGK1CAMKK2 | |
| SCHEMBL16948899 | 0.91 | MAP3K11 (0.41) | MAP3K11KITAXLSGK1CAMKK2 | |
| SCHEMBL18238184 | 0.91 | MAP3K11 (0.41) | MAP3K11KITAXLSGK1CAMKK2 | |
| SCHEMBL18238242 | 0.90 | AXL (0.53) | MAP3K11AXLSGK1CAMKK2CDK2 | |
| SCHEMBL16949043 | 0.90 | AXL (0.53) | MAP3K11AXLSGK1CAMKK2CDK2 | |
| SCHEMBL18250466 | 0.89 | AAK1 (0.47) | MAP3K11KITAXLSGK1CAMKK2 | |
| SCHEMBL18238835 | 0.89 | AXL (0.45) | MAP3K11AXLSGK1CAMKK2CDK2 | |
| SCHEMBL16949395 | 0.89 | AXL (0.45) | MAP3K11AXLSGK1CAMKK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |