Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 12/20 | 0.53 |
| ▸ | TAB1 | Q15750 | 12/20 | 0.53 |
| ▸ | GSK3B | P49841 | 6/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16945143 | 1.00 | MAP3K7 (0.53) | MAP3K7TAB1GSK3BCDC7PLK4 | |
| SCHEMBL18238269 | 0.89 | MAP3K7 (0.46) | MAP3K7TAB1GSK3BNTRK1 | |
| SCHEMBL16945189 | 0.89 | MAP3K7 (0.46) | MAP3K7TAB1GSK3BNTRK1 | |
| SCHEMBL18250498 | 0.88 | GSK3B (0.42) | MAP3K7TAB1GSK3BAXLMET | |
| SCHEMBL1714507 | 0.82 | KMT2A (0.51) | GSK3BPLK4AURKAROCK2PRKD3 | |
| SCHEMBL16932960 | 0.82 | GSK3B (0.56) | MAP3K7TAB1GSK3BCDC7PLK4 | |
| SCHEMBL16932959 | 0.82 | GSK3B (0.56) | MAP3K7TAB1GSK3BCDC7PLK4 | |
| SCHEMBL4346709 | 0.81 | MAP3K7 (0.48) | MAP3K7TAB1AURKAROCK2NTRK1 | |
| SCHEMBL4346713 | 0.81 | MAP3K7 (0.48) | MAP3K7TAB1AURKAROCK2NTRK1 | |
| SCHEMBL16945147 | 0.81 | MAP3K7 (0.46) | MAP3K7TAB1GSK3BNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |