Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 10/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16949409 | 1.00 | AXL (0.47) | AXLGSK3BCDC7PLK4CHEK1 | |
| SCHEMBL16949002 | 0.92 | AAK1 (0.42) | AXLGSK3BCDC7PLK4CHEK1 | |
| SCHEMBL18238690 | 0.92 | AAK1 (0.42) | AXLGSK3BCDC7PLK4CHEK1 | |
| SCHEMBL16948748 | 0.90 | ITK (0.41) | AXLGSK3BCDC7PLK4CHEK1 | |
| SCHEMBL18238284 | 0.90 | ITK (0.41) | AXLGSK3BCDC7PLK4CHEK1 | |
| SCHEMBL18250476 | 0.90 | AXL (0.39) | AXLGSK3BCDC7PLK4CHEK1 | |
| SCHEMBL18238802 | 0.89 | AXL (0.42) | AXLGSK3BCDC7PLK4CHEK1 | |
| SCHEMBL16949120 | 0.89 | AXL (0.42) | AXLGSK3BCDC7PLK4CHEK1 | |
| SCHEMBL16949001 | 0.89 | BRD4 (0.47) | AXLLYNCDK2SYKMAPK8 | |
| SCHEMBL18238334 | 0.89 | BRD4 (0.47) | AXLLYNCDK2SYKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |