Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 4/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.42 |
| ▸ | AXL | P30530 | 4/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.41 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16949144 | 1.00 | SGK1 (0.43) | SGK1MAP3K11CAMKK2AXLAAK1 | |
| SCHEMBL16948923 | 0.92 | MAP3K11 (0.42) | SGK1MAP3K11CAMKK2AXLAAK1 | |
| SCHEMBL18238067 | 0.92 | MAP3K11 (0.42) | SGK1MAP3K11CAMKK2AXLAAK1 | |
| SCHEMBL18238666 | 0.92 | SGK1 (0.40) | SGK1MAP3K11CAMKK2AXLAAK1 | |
| SCHEMBL16948906 | 0.92 | SGK1 (0.40) | SGK1MAP3K11CAMKK2AXLAAK1 | |
| SCHEMBL16948892 | 0.89 | AAK1 (0.42) | SGK1MAP3K11CAMKK2AXLAAK1 | |
| SCHEMBL18238621 | 0.89 | AAK1 (0.42) | SGK1MAP3K11CAMKK2AXLAAK1 | |
| SCHEMBL16949003 | 0.89 | AXL (0.38) | SGK1MAP3K11CAMKK2AXLAAK1 | |
| SCHEMBL18239059 | 0.89 | AXL (0.38) | SGK1MAP3K11CAMKK2AXLAAK1 | |
| SCHEMBL18250466 | 0.89 | AAK1 (0.47) | SGK1MAP3K11CAMKK2AXLAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499551-B2 | Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases | CONFLUENCE LIFE SCIENCES, INC. (US) | 2016-11-22 | — | — | US | disclosed |