Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19153433 | 0.78 | ADORA2A (0.59) | ADORA2AADORA1KDM4ECCR8AXL | |
| SCHEMBL5067972 | 0.78 | AXL (0.38) | AXLPRKCINUDT1 | |
| SCHEMBL19131803 | 0.74 | ADORA2A (0.50) | ADORA2AADORA1KDM4ECCR8AXL | |
| SCHEMBL10505142 | 0.73 | ADORA1 (0.40) | ADORA2AADORA1KMT2AALDH1A1GLA | |
| SCHEMBL15557725 | 0.71 | PRKCI (0.39) | ADORA2AADORA1AXLPRKCIDYRK1A | |
| SCHEMBL11610965 | 0.71 | ADORA2A (0.46) | ADORA2AADORA1KDM4ECCR8AXL | |
| SCHEMBL10505990 | 0.70 | ADORA2A (0.53) | ADORA2AADORA1KDM4EAXLPRKCI | |
| SCHEMBL12113604 | 0.69 | JAK2 (0.44) | ADORA2AADORA1KDM4EAXLPRKCI | |
| SCHEMBL16478434 | 0.69 | ADORA2A (0.40) | ADORA2AADORA1AXLPRKCIDYRK1A | |
| SCHEMBL10505531 | 0.69 | PIK3CA (0.45) | ADORA2AADORA1CCR8PRKCIDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183359-A1 | SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME | BLINKBIO, INC. (US) | 2016-11-17 | — | — | WO | disclosed |