Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | CD38 | P28907 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13292198 | 0.84 | BRAF (0.59) | CLK4EGFRCYP1A2CYP3A4LMNA | |
| SCHEMBL4890693 | 0.81 | PI4KB (0.68) | CLK4DYRK1AEGFRCYP1A2CYP3A4 | |
| SCHEMBL1824255 | 0.81 | EGFR (0.50) | CLK4DYRK1AEGFRCYP1A2CYP3A4 | |
| SCHEMBL1824864 | 0.80 | RIPK2 (0.60) | CD38MAP4K4 | |
| SCHEMBL1823059 | 0.80 | KDM4E (0.61) | EGFRCYP1A2CYP3A4LMNACYP2D6 | |
| SCHEMBL1823364 | 0.79 | MAPT (0.64) | CLK4EGFRCYP1A2CYP3A4LMNA | |
| SCHEMBL1823186 | 0.79 | PIK3CA (0.61) | CLK4DYRK1AEGFRCYP1A2CYP3A4 | |
| SCHEMBL1823225 | 0.79 | MAPT (0.48) | EGFRLMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL29450569 | 0.78 | RAF1 (0.58) | CLK4EGFRCYP1A2CYP3A4LMNA | |
| SCHEMBL1825395 | 0.78 | EGFR (0.52) | CLK4EGFRCYP1A2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981876-B1 | TRIAZOLOANILINOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS | ARROW THERAPEUTICS LTD (GB) | 2011-05-04 | — | — | EP | disclosed |