Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.47 |
| ▸ | SCN1A | P35498 | 2/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17423323 | 0.99 | SCN9A (0.52) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| Hydrochloric Acid SCHEMBL18263271 | 0.99 | SCN9A (0.52) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL15535884 | 0.88 | SCN9A (0.66) | SCN9ASCN5A | |
| SCHEMBL29028643 | 0.88 | SCN9A (0.53) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL16770869 | 0.85 | SCN9A (0.49) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| Hydrochloric Acid SCHEMBL16758826 | 0.84 | SCN9A (0.48) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL29028780 | 0.82 | SCN9A (0.42) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL17422972 | 0.81 | SCN9A (0.57) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL16758808 | 0.80 | SCN9A (0.55) | SCN9ASCN5A | |
| SCHEMBL15536887 | 0.80 | SCN9A (0.73) | SCN9ASCN5ASCN1ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10179767-B2 | Substituted benzamides and methods of use thereof | GENENTECH, INC. (US) | 2019-01-15 | — | — | US | disclosed |
| EP-3297989-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016191312-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-12-01 | — | — | WO | disclosed |
| US-20160340309-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179767-B2 | Substituted benzamides and methods of use thereof | SCN7A, SCN2B, SCN5A | SCN9A 12/4885SCN5A 3/4885SCN1A 4/4885 |
| US-20160340309-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | SCN7A, SCN2B, SCN5A | SCN9A 12/4885SCN5A 3/4885SCN1A 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.