SCHEMBL18255227

SCHEMBL18255227

C[SiH](C)CCOCn1cc(C#N)nc1C(=O)Nc1ccc(C2CCS(=O)(=O)CC2)cc1C1=CCCCC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIT P10721 11/20 0.54
CSF1R P07333 17/20 0.46
NTRK1 P04629 4/20 0.46
LCK P06239 4/20 0.46
AXL P30530 4/20 0.46
FLT3 P36888 4/20 0.46
CYP3A4 P08684 3/20 0.46
BMPR1B O00238 2/20 0.46
PLK4 O00444 2/20 0.46
STK25 O00506 2/20 0.46
RIOK3 O14730 2/20 0.46
CHEK1 O14757 2/20 0.46
GAK O14976 2/20 0.46
DCLK1 O15075 2/20 0.46
MUSK O15146 2/20 0.46
EPHB6 O15197 2/20 0.46
PDPK1 O15530 2/20 0.46
MAP3K13 O43283 2/20 0.46
DAPK3 O43293 2/20 0.46
MAP3K7 O43318 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4980504 0.91 KIT (0.54) KITCSF1RNTRK1LCKAXL
SCHEMBL18307002 0.83 KIT (0.55) KITCSF1RNTRK1LCKAXL
SCHEMBL4982409 0.82 CSF1R (0.57) KITCSF1RNTRK1LCKAXL
SCHEMBL1856316 0.82 CSF1R (0.57) KITCSF1RNTRK1LCKAXL
SCHEMBL1859661 0.82 CSF1R (0.59) KITCSF1RNTRK1LCKAXL
SCHEMBL2938195 0.81 KIT (0.57) KITCSF1RNTRK1LCKAXL
SCHEMBL4981745 0.81 KIT (0.58) KITCSF1RNTRK1LCKAXL
SCHEMBL4986921 0.80 CSF1R (0.62) KITCSF1RNTRK1LCKAXL
SCHEMBL1855569 0.80 CSF1R (0.58) KITCSF1RNTRK1LCKAXL
SCHEMBL1865625 0.80 CSF1R (0.57) KITCSF1RNTRK1LCKAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1807077-B1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2016-11-23 EP disclosed